Chemical Constituents from Oroxylum Indicum (l.) Kurz of Nepalese Origin

Oroxylum indicum commonly called Indian tumplet flower (Nepali name: Tatelo, Karamkanda, saune tatal) belongs to the Bignoniaceae family and it is widely used in traditional medicine.1, 2 Traditionally, the stem, bark, seeds and leaves used for the treatment of the diarrhea, typhoid and stomachache. It has also been used as antitussive, analgesic and anti-inflammatory agents for the treatment of cough, bronchitis and other lungs diseases. Considering its wide traditional uses we have carried out phytochemical studies on Oroxylum indicum to isolate its biologically active compounds. In the present study we have isolated four pure compounds (1-4) from the stem bark of O. indicum. The structure of isolated compounds was established on the basis of spectral analysis. Furthermore, the isolated compounds were showed the toxicity towards the brine-shrimp and they inhibited the growth of Gram-positive and Gram-negative bacteria.